We're thrilled to congratulate Dr. Ghayah Bahatheg on her latest publication titled "Antibacterial peptidomimetics based on guanidine-functionalized di-tertiary amides" in RSC Medicinal Chemistry!
This groundbreaking research presents a new class of antibacterial peptidomimetics that combine the stability of peptoids with the membrane-targeting properties of guanidine groups. The study demonstrates potent activity against key bacterial pathogens including S. aureus, E. coli, and P. aeruginosa, with some molecules also capable of disrupting persistent bacterial biofilms. Importantly, the most active compounds were found to be non-toxic at effective concentrations, making them promising candidates for therapeutic applications.
Publication details:
- Journal: RSC Medicinal Chemistry
- Title: Antibacterial peptidomimetics based on guanidine-functionalized di-tertiary amides
- Authors: Ghayah Bahatheg, Rajesh Kuppusamy, Lissy Hartmann, Charles Gordon Cranfield, David StClair Black, Mark D. P. Willcox, and Naresh Kumar
- Published: October 2025
- DOI: 10.1039/D5MD00688K